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Macrophage polarization was assessed by flow cytometry using F4/80, CD11b, CD206, and CD86 markers, while biodistribution studies with DiR-labeled EVs demonstrated primary accumulation in the colon and liver
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In contrast, treatment with ASTA diminished the elevated CK-MB by 56%, LDH by 54%, serum urea by 73%, and creatinine by 61%, compared to DC, bringing levels close to normal control values, indicating a protective effect on both myocardial and renal functions
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