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Dysregulated autophagy also disrupts the antioxidant defense system in vitiligo melanocytes (Qiao et al., 2016) making these cells more prone to senescence and cell death (Zhang et al., 2015
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Fucoxanthin also modulates cell cycle progression by inducing G0/G1 phase arrest through downregulation of cyclin D1, cyclin‐dependent kinase 4 (CDK4), and retinoblastoma protein (Rb) phosphorylation [111]
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