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Unlike its cyclic counterpart Melanotan II, MT-1 retains a linear backbone analogous to the 13-amino-acid natural α-MSH sequence, differing primarily in a norleucine substitution at position 4 and a D-phenylalanine at position 7 (Nle⁴-D-Phe⁷-α-MSH), which confer receptor selectivity and enhanced metabolic stability

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In a 1984 withdrawal study involving 107 subjects, FDA reported no significant adverse events in 95