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Nevertheless, despite advances in single-cell RNA sequencing and spatial transcriptomics, detecting low-abundance ORs remains challenging due to their minimal transcript levels

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During the early stages of tendon healing, infiltrating macrophages at the site of injury are predominantly of the M1 phenotype (77), and their concentration increases significantly during the first 2 weeks of tendon healing and is localized to newly formed tendon tissues and areas of tissue remodeling (71), where the M1 macrophages migrate to the site of injury and release pro-inflammatory cytokines, such as interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), which may hinder tissue repair (71)